CaseStudy2_Questions

Lifestyle trajectories and ischaemic heart diseases: a prospective cohort study in UK Biobank

Q: What is the primary outcome of the study? A: The primary outcome of the study is the incidence of ischaemic heart disease (IHD) events, which include myocardial infarction, angina, and coronary revascularization.

Q: What is the study design? A: The study is a prospective cohort study that follows participants over time to assess the relationship between lifestyle trajectories and the incidence of IHD. T: Prospective cohort study F: Retrospective cohort study F: Cross-sectional study F: Randomized controlled trial

Q: What was the sample size? A: The study included 502,643 participants from the UK Biobank, with a mean age of 56.5 years at baseline.

Q: What were the inclusion/ exclusion criteria? A: Participants were included if they were aged 40-69 years at baseline, had complete data on lifestyle factors, and had no history of IHD at baseline.

Q: What analysis was used to assess the primary outcome? A: The primary outcome was assessed using Cox proportional hazards models, which estimated the hazard ratios for IHD events based on different lifestyle trajectories.

Q: What secondary analyses were performed? A:

Q: What confounding factors were adjusted for? A:

Q: Were any assumption tests reported? A: Yes, the authors reported that the proportional hazards assumption was met for the Cox models used in the analysis, havign tested using Schoenfeld residuals.

Q: How much missing data was there? A: The study reported that 6.2% of the data were missing for the lifestyle factors.

Q: How was the missing data handled? A: Multiple imputation was used to handle missing data, with 20 imputed datasets created for the analysis.